This video explains hemoglobinopathies including sickle cell anaemia and thalassemia .It also includes case discussion of sickle cell anaemia
Timeline for Hemoglobinopathies video:
00:00 Introduction to hemoglobinopathies
02:13 Introduction to Sickle cell anaemia ( Qualitative /structural defect)
03:46 Why sickle cell is called molecular disease
07:50 Why RBCs turned to sickle in shape (mechanism of sticky patch)
10:15 mechanism behind painful crisis in sickle cell disease
11:59 Homozygous vs Heterozygous HbS ( Sickle cell disease vs Sickle cell trait )
13:35 clinical features of sickle cell anaemia
15:17 Diagnosis of sickle cell (solubility test/sickling test/Hb electrophoresis)
16:55 hemoglobin electrophoresis for sickle cell anaemia
20:53 Other abnormal structural Hemoglobinopathies
22:52 Management of sickle cell anaemia
25:00 Introduction to Thalassemia
26:06 Alpha thalassemia
27:42 Beta thalassemia
29:50 Summary of Hemoglobinopathies
31:24 Case discussion of sickle cell anemia
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video on Structure and function of Hemoglobin : [ Ссылка ]
Agarose Hemoglobin electrophoresis procedure video : [ Ссылка ]
Cellulose hemoglobin electrophoresis video : [ Ссылка ]
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Qualitative defect /Structural defect : HbS, HbE, HbC etc
Quantitative defect : Defective globin chain production - Thalassemia ( two types alpha thalassea
pathophysiology of sickle cell anaemia ( beta chain glutamic acid replaced by valine at 6th position)
#hemoglobinopathies
#sicklecellanaemia
#thalassemia
#sicklecelldisease
#sicklecelltrait
#alphathalassemia
#betathalassemia
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