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Drugs that activate muscarinic receptors in the peripheral nervous system are called parasympathomimetic drugs because they mimic the effects of acetylcholine on the parasympathetic nervous system. An example of a parasympathomimetic drug is pilocarpine, which is a nonspecific muscarinic agonist. Parasympathomimetic drugs activate the parasympathetic nervous system. (PSNS). As the neurotransmitter of the PSNS is acetylcholine (ACh), parasympathomimetics are also called cholinomimetic agents. These are classified according to whether they act as direct agonists of acetylcholine receptors

(AChR) or indirect agonists of AChR (also called anticholinesterase). While direct agonists act by binding directly to muscarinic or nicotinic ACh receptors, indirect agonists prolong the action of endogenous acetylcholine by inhibiting acetylcholinesterase (AChE). Direct agonists of AChR are used topically in ophthalmology to induce miosis, while indirect agonists are used to treat conditions such as postoperative ileus, urinary retention, and myasthenia gravis

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