Corrective measures have to be taken as far as uterine factors the embryonic factors is a mandate, how do we correct uterine actors? First we need to identify and we just said that we have to do all those tests and if we find a fibroid, and if a fibroid is greater than 4 cm, or you find a fibroid that is greater than 2 cms, but it is jutting into the uterine cavity, so it becomes a space occupying lesion within the uterus, doesn’t allow the embryo to attach to the uterus. We should consider removing those kind of fibroids. Second is if you have some kind of small growths like polyps, then that needs to be removed. If there is a band inside the uterus called as the intrauterine septum, or adhesions cynicae, yes, they ned to be cut and the uterus need to be optimised with medications to improve upon the uterine lining before you can think about the next uterine transfer when you do not find these kind of issues and still there an implantation failure, then one can think about the genetic profile of the endometrium. Uterus can be understood called as the endometrial receptivity assay. It is called the ERA test. So that could also be considered to optimise on the time or the window of implantation. The time when the gene expression of that endometrium is at its peak so that it will able to attach the embryo. Other corrections that we them medications for 2 or 3 months prior to taking them up. Nothing much can be done as a corrective measure for chromosomal abnormalities, but they are of the nature of which are the cause for the embryos to be chromosomally abnormal. Then we change the gamete if it is in the sperm go in for the donation of sperms. If the factor is repeated and if it is coming in for the maternal side, from the egg, then we advise such patients to go in for an oocyte donation. To understand the genetic abnormality of the embryo, PGS is highly recommended and it also helps. The time to [regency is dramatically reduced when one goes through the process of BGS an out of a set or a cohort of 8 to 10 embryos, you do not know which is normal, which is abnormal. Every time we transfer 2 to or 3 cycles so repeated embryo transfer cycles that a women goes through can be avoided by picking what is the best embryo for an embryo transfer process so these are the corrective measures that one needs to think before giving them another cycle.

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