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In part 1, Quiñones-Hinojosa discusses the history of brain tumors, different types of tumors (non-cancerous vs cancerous) and what this means for treatment and prognosis. He then focuses on a specific type of tumor, glioblastoma multiforme, and outlines what oncologists and surgeons have learned about this cancer over the past 30 years and how this information has influenced treatment. He closes with a brief overview of what is known about brain tumor stem cells.

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