Most common cause of nephrotic syndrome in children
Path: T-cell–mediated injury to podocytes → ↑ molecular permeability to albumin
Symptoms:
Edema (eg, periorbital, scrotal, generalized)
Fatigue
± Abdominal pain
Diagnosis:
Urine: nephrotic-range proteinuria
Serum: hypoalbuminemia ± hyperlipidemia
(Not required) kidney biopsy: diffuse effacement of foot processes on EM
Treat with corticosteroids
Prognosis
Most remit; relapse is common
Low risk of chronic kidney disease if episodes are steroid responsive
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